Connexin 47 Mutations Increase Risk for Secondary Lymphedema Following Breast Cancer Treatment
Identifieur interne : 004949 ( Main/Exploration ); précédent : 004948; suivant : 004950Connexin 47 Mutations Increase Risk for Secondary Lymphedema Following Breast Cancer Treatment
Auteurs : David N. Finegold [États-Unis] ; Catherine J. Baty [États-Unis] ; Kelly Z. Knickelbein [États-Unis] ; Shelley Perschke [États-Unis] ; Sarah E. Noon [États-Unis] ; Diana Campbell [États-Unis] ; Jenny M. Karlsson [États-Unis] ; Diana Huang [États-Unis] ; Mark A. Kimak [États-Unis] ; Elizabeth C. Lawrence [États-Unis] ; Eleanor Feingold [États-Unis] ; Stephen D. Meriney [États-Unis] ; Adam M. Brufsky [États-Unis] ; Robert E. Ferrell [États-Unis]Source :
- Clinical cancer research [ 1078-0432 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Cellules HeLa, Connexines (génétique), Facteurs de risque, Femelle, Humains, Jeune adulte, Lignée cellulaire tumorale, Lymphoedème (génétique), Lymphoedème (traitement médicamenteux), Prédisposition génétique à une maladie, Sujet âgé, Sujet âgé de 80 ans ou plus, Séquence nucléotidique, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Tumeurs du sein (génétique), Tumeurs du sein (traitement médicamenteux), Études cas-témoins.
- MESH :
- anatomopathologie : Tumeurs du sein.
- génétique : Connexines, Lymphoedème, Tumeurs du sein.
- traitement médicamenteux : Lymphoedème, Tumeurs du sein.
- Pascal (Inist)
- Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Cellules HeLa, Connexine, Facteurs de risque, Femelle, Humains, Jeune adulte, Lignée cellulaire tumorale, Mutation, Génétique, Facteur risque, Prédisposition génétique à une maladie, Secondaire, Lymphoedème, Cancer du sein, Sujet âgé, Sujet âgé de 80 ans ou plus, Séquence nucléotidique, Traitement, Tumeurs du sein, Études cas-témoins.
- Wicri :
- topic : Génétique.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Base Sequence, Breast Neoplasms (drug therapy), Breast Neoplasms (genetics), Breast Neoplasms (pathology), Breast Neoplasms (surgery), Breast cancer, Case-Control Studies, Cell Line, Tumor, Connexin, Connexins (genetics), Female, Genetic Predisposition to Disease, Genetics, HeLa Cells, Humans, Lymphedema, Lymphedema (drug therapy), Lymphedema (genetics), Middle Aged, Mutation, Risk Factors, Risk factor, Secondary, Sequence Analysis, DNA, Treatment, Young Adult.
- MESH :
- chemical , genetics : Connexins.
- drug therapy : Breast Neoplasms, Lymphedema.
- genetics : Breast Neoplasms, Lymphedema.
- pathology : Breast Neoplasms.
- surgery : Breast Neoplasms.
- Adult, Aged, Aged, 80 and over, Base Sequence, Case-Control Studies, Cell Line, Tumor, Female, Genetic Predisposition to Disease, HeLa Cells, Humans, Middle Aged, Risk Factors, Sequence Analysis, DNA, Young Adult.
Abstract
Purpose: Secondary lymphedema is a frequent complication of breast cancer associated with surgery, chemotherapy, or radiation following breast cancer treatment. The potential contribution of genetic susceptibility to risk of developing secondary lymphedema following surgical trauma, radiation, and other tissue insults has not been studied. Experimental Design: To determine whether women with breast cancer and secondary lymphedema had mutations in candidate lymphedema genes, we undertook a case-control study of 188 women diagnosed with breast cancer recruited from the University of Pittsburgh Breast Cancer Program (http:// www.upmccancercenter.com/breast/index.cfm) between 2000 and 2010. Candidate lymphedema genes, GJC2 (encoding connexin 47 [Cx47]), FOXC2, HGF, MET, and FLT4 (encoding VEGFR3), were sequenced for mutation. Bioinformatics analysis and in vitro functional assays were used to confirm significance of novel mutations. Results: Cx47 mutations were identified in individuals having secondary lymphedema following breast cancer treatment but not in breast cancer controls or normal women without breast cancer. These novel mutations are dysfunctional as assessed through in vitro assays and bioinformatics analysis and provide evidence that altered gap junction function leads to lymphedema. Conclusions: Our findings challenge the view that secondary lymphedema is solely due to mechanical trauma and support the hypothesis that genetic susceptibility is an important risk factor for secondary lymphedema. A priori recognition of genetic risk (i) raises the potential for early detection and intervention for a high-risk group and (ii) allows the possibility of altering surgical approach and/or chemo- and radiation therapy, or direct medical treatment of secondary lymphedema with novel connexin-modifying drugs.
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Affiliations:
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Le document en format XML
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Finegold</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pediatrics, University of Pittsburgh School of Medicine</s1><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Pediatrics, University of Pittsburgh School of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Baty, Catherine J" sort="Baty, Catherine J" uniqKey="Baty C" first="Catherine J." last="Baty">Catherine J. Baty</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cell Biology & Physiology, and, University of Pittsburgh School of Medicine</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Cell Biology & Physiology, and, University of Pittsburgh School of Medicine</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Knickelbein, Kelly Z" sort="Knickelbein, Kelly Z" uniqKey="Knickelbein K" first="Kelly Z." last="Knickelbein">Kelly Z. Knickelbein</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Perschke, Shelley" sort="Perschke, Shelley" uniqKey="Perschke S" first="Shelley" last="Perschke">Shelley Perschke</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Noon, Sarah E" sort="Noon, Sarah E" uniqKey="Noon S" first="Sarah E." last="Noon">Sarah E. Noon</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Campbell, Diana" sort="Campbell, Diana" uniqKey="Campbell D" first="Diana" last="Campbell">Diana Campbell</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Karlsson, Jenny M" sort="Karlsson, Jenny M" uniqKey="Karlsson J" first="Jenny M." last="Karlsson">Jenny M. Karlsson</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cell Biology & Physiology, and, University of Pittsburgh School of Medicine</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Cell Biology & Physiology, and, University of Pittsburgh School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Diana" sort="Huang, Diana" uniqKey="Huang D" first="Diana" last="Huang">Diana Huang</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Cell Biology & Physiology, and, University of Pittsburgh School of Medicine</s1><s3>USA</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Cell Biology & Physiology, and, University of Pittsburgh School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Kimak, Mark A" sort="Kimak, Mark A" uniqKey="Kimak M" first="Mark A." last="Kimak">Mark A. Kimak</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Lawrence, Elizabeth C" sort="Lawrence, Elizabeth C" uniqKey="Lawrence E" first="Elizabeth C." last="Lawrence">Elizabeth C. Lawrence</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Feingold, Eleanor" sort="Feingold, Eleanor" uniqKey="Feingold E" first="Eleanor" last="Feingold">Eleanor Feingold</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Meriney, Stephen D" sort="Meriney, Stephen D" uniqKey="Meriney S" first="Stephen D." last="Meriney">Stephen D. Meriney</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Neuroscience, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Brufsky, Adam M" sort="Brufsky, Adam M" uniqKey="Brufsky A" first="Adam M." last="Brufsky">Adam M. Brufsky</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of Pittsburgh School of Medicine</s1><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Medicine, University of Pittsburgh School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Ferrell, Robert E" sort="Ferrell, Robert E" uniqKey="Ferrell R" first="Robert E." last="Ferrell">Robert E. Ferrell</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</s1><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Department of Human Genetics, University of Pittsburgh Graduate School of Public Health</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Clinical cancer research</title><title level="j" type="abbreviated">Clin. cancer res.</title><idno type="ISSN">1078-0432</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical cancer research</title><title level="j" type="abbreviated">Clin. cancer res.</title><idno type="ISSN">1078-0432</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Base Sequence</term><term>Breast Neoplasms (drug therapy)</term><term>Breast Neoplasms (genetics)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (surgery)</term><term>Breast cancer</term><term>Case-Control Studies</term><term>Cell Line, Tumor</term><term>Connexin</term><term>Connexins (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genetics</term><term>HeLa Cells</term><term>Humans</term><term>Lymphedema</term><term>Lymphedema (drug therapy)</term><term>Lymphedema (genetics)</term><term>Middle Aged</term><term>Mutation</term><term>Risk Factors</term><term>Risk factor</term><term>Secondary</term><term>Sequence Analysis, DNA</term><term>Treatment</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Cellules HeLa</term><term>Connexines (génétique)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lignée cellulaire tumorale</term><term>Lymphoedème (génétique)</term><term>Lymphoedème (traitement médicamenteux)</term><term>Prédisposition génétique à une maladie</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Séquence nucléotidique</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Tumeurs du sein (génétique)</term><term>Tumeurs du sein (traitement médicamenteux)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Connexins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Connexines</term><term>Lymphoedème</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Base Sequence</term><term>Case-Control Studies</term><term>Cell Line, Tumor</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>HeLa Cells</term><term>Humans</term><term>Middle Aged</term><term>Risk Factors</term><term>Sequence Analysis, DNA</term><term>Young Adult</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de séquence d'ADN</term><term>Cellules HeLa</term><term>Connexine</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lignée cellulaire tumorale</term><term>Mutation</term><term>Génétique</term><term>Facteur risque</term><term>Prédisposition génétique à une maladie</term><term>Secondaire</term><term>Lymphoedème</term><term>Cancer du sein</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Séquence nucléotidique</term><term>Traitement</term><term>Tumeurs du sein</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: Secondary lymphedema is a frequent complication of breast cancer associated with surgery, chemotherapy, or radiation following breast cancer treatment. The potential contribution of genetic susceptibility to risk of developing secondary lymphedema following surgical trauma, radiation, and other tissue insults has not been studied. Experimental Design: To determine whether women with breast cancer and secondary lymphedema had mutations in candidate lymphedema genes, we undertook a case-control study of 188 women diagnosed with breast cancer recruited from the University of Pittsburgh Breast Cancer Program (http:// www.upmccancercenter.com/breast/index.cfm) between 2000 and 2010. Candidate lymphedema genes, GJC2 (encoding connexin 47 [Cx47]), FOXC2, HGF, MET, and FLT4 (encoding VEGFR3), were sequenced for mutation. Bioinformatics analysis and in vitro functional assays were used to confirm significance of novel mutations. Results: Cx47 mutations were identified in individuals having secondary lymphedema following breast cancer treatment but not in breast cancer controls or normal women without breast cancer. These novel mutations are dysfunctional as assessed through in vitro assays and bioinformatics analysis and provide evidence that altered gap junction function leads to lymphedema. Conclusions: Our findings challenge the view that secondary lymphedema is solely due to mechanical trauma and support the hypothesis that genetic susceptibility is an important risk factor for secondary lymphedema. A priori recognition of genetic risk (i) raises the potential for early detection and intervention for a high-risk group and (ii) allows the possibility of altering surgical approach and/or chemo- and radiation therapy, or direct medical treatment of secondary lymphedema with novel connexin-modifying drugs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Finegold, David N" sort="Finegold, David N" uniqKey="Finegold D" first="David N." last="Finegold">David N. Finegold</name></noRegion><name sortKey="Baty, Catherine J" sort="Baty, Catherine J" uniqKey="Baty C" first="Catherine J." last="Baty">Catherine J. Baty</name><name sortKey="Baty, Catherine J" sort="Baty, Catherine J" uniqKey="Baty C" first="Catherine J." last="Baty">Catherine J. Baty</name><name sortKey="Brufsky, Adam M" sort="Brufsky, Adam M" uniqKey="Brufsky A" first="Adam M." last="Brufsky">Adam M. Brufsky</name><name sortKey="Campbell, Diana" sort="Campbell, Diana" uniqKey="Campbell D" first="Diana" last="Campbell">Diana Campbell</name><name sortKey="Feingold, Eleanor" sort="Feingold, Eleanor" uniqKey="Feingold E" first="Eleanor" last="Feingold">Eleanor Feingold</name><name sortKey="Ferrell, Robert E" sort="Ferrell, Robert E" uniqKey="Ferrell R" first="Robert E." last="Ferrell">Robert E. Ferrell</name><name sortKey="Finegold, David N" sort="Finegold, David N" uniqKey="Finegold D" first="David N." last="Finegold">David N. Finegold</name><name sortKey="Huang, Diana" sort="Huang, Diana" uniqKey="Huang D" first="Diana" last="Huang">Diana Huang</name><name sortKey="Karlsson, Jenny M" sort="Karlsson, Jenny M" uniqKey="Karlsson J" first="Jenny M." last="Karlsson">Jenny M. Karlsson</name><name sortKey="Kimak, Mark A" sort="Kimak, Mark A" uniqKey="Kimak M" first="Mark A." last="Kimak">Mark A. Kimak</name><name sortKey="Knickelbein, Kelly Z" sort="Knickelbein, Kelly Z" uniqKey="Knickelbein K" first="Kelly Z." last="Knickelbein">Kelly Z. Knickelbein</name><name sortKey="Lawrence, Elizabeth C" sort="Lawrence, Elizabeth C" uniqKey="Lawrence E" first="Elizabeth C." last="Lawrence">Elizabeth C. Lawrence</name><name sortKey="Meriney, Stephen D" sort="Meriney, Stephen D" uniqKey="Meriney S" first="Stephen D." last="Meriney">Stephen D. Meriney</name><name sortKey="Noon, Sarah E" sort="Noon, Sarah E" uniqKey="Noon S" first="Sarah E." last="Noon">Sarah E. Noon</name><name sortKey="Perschke, Shelley" sort="Perschke, Shelley" uniqKey="Perschke S" first="Shelley" last="Perschke">Shelley Perschke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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